Optimizing CAR-T cell activity to treat Non-Hodgkin’s lymphoma and leukemia

Amplify and train CAR-T cells to deliver more potent anti-cancer activity—ultimately, enabling the cure of previously fatal lymphomas and leukemias.

Optimizing CAR-T cell activity to treat Non-Hodgkin’s lymphoma and leukemia
Albert Einstein College of Medicine
Albert Einstein College of Medicine
New York, United States
Dr. Harris Goldstein

Dr. Harris Goldstein







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Project Summary

Lymphoma impacts the lymph system, which functions within the immune system—meaning the place that fights infection and disease in your body is under attack by this type of cancer. While the infected cells begin in places such as lymph nodes, the spleen, and digestive tract, it is a rapidly progressive disease that can aggressively grow and spread.

We want to train cells to deliver more potent anti-cancer activity. We will work with highly immunodeficient mice to create a model to evaluate our CAR-T cell therapy approach. It is our near-term aim to advance into clinical trial design and implementation to treat relapsed lymphoma and leukemia. To get there, our year-long Phase 1 will focus on perfecting concept, experimental protocol, and initial testing.

Project Length1 year
GoalLaunch preliminary research to create the most effective strategy for CAR-T cells to attack malignant cells
Research TypeExploratory
Research Team