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ImYoo is matching all funds up to $42,430!

Which rheumatoid arthritis drug works for me?

We designed this research with RA patients and now we're crowdsourcing the science with the community. The power to research firstline RA drugs is in your hands: Participate in this study! Fund. Share.


San Francisco, USA


Tatyana Dobreva, PhDDavid Brown

Tatyana Dobreva, PhD

David Brown

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$3,382of $84,860 goal
$40,739 in matching funds


80% of people with rheumatoid arthritis have adverse side effects to first line therapy.

Latest Activity

Project Summary

Rheumatoid arthritis patients have to go through a series of drugs before finding one that works for them. While trying out firstline drugs such as methotrexate, many patients experience a series of debilitating side-effects, such as nausea, fatigue, and infections, causing them to discontinue their usage. Currently, there are limited tests available to tell a patient whether a drug will work for them, which could potentially save them time, money, and prevent a painful experience. Tools such as single-cell RNA sequencing provide high-resolution snapshots into the behavior of many different immune cells in a person’s blood. By combining single-cell immune profiling and at-home capillary blood self-collection, we are looking to understand why first line of defense drugs work for some people and not others. For a behind-the-scenes view of how we made this study happen, check out our blog on Medium!

Project Length6-8 weeks
GoalOur primary goal is to collect samples from rheumatoid arthritis patients starting a firstline therapy and use their high-resolution immune profiles to predict responders and non-responders. Our secondary goal is to track these patients before, during, and after their drug regimen to more precisely characterize why the drug is failing to work and why some patients experience more severe side-effects than others.
Research TypeExploratory Research, Pre-clinical research
Research Team
ImYoo is matching all funds up to $42,430!


Decentralizing immune studies with at-home blood collection and high-resolution data

ImYoo is a Public Benefit Corporation. Therefore we are dedicating a portion of our revenue to enriching society’s understanding of human health. We believe that scientific discovery is a group effort, so we are matching your support for this first crowdfunded project. Rheumatoid arthritis (RA) patients need help finding the best treatments for them. We formed the RA Working Group to do something about it.

We believe in radical transparency and collaboration. That means every step of the process, from study design to funding to final results and analysis are visible to you. This project is a joint effort between participants and researchers, so we are showing you all the costs involved in this research, including the portion our team is covering.